[1] It introduced his recurring hero Lone Sloane and played on science-fiction themes partially inspired by his favourite writers, H. P. Lovecraft and A.E.

After Druillet became a regular contributor to the Franco-Belgian comics magazine Pilote in 1970, his Lone Sloane saga grew steadily more flamboyant as he pursued innovative new imagery, including bold page designs and computer-generated images.

His backdrops of gigantic structures inspired by Art Nouveau, indigenous architecture, and Gothic cathedrals earned him the nickname of "space architect".

In 1975, Druillet joined Jean-Pierre Dionnet, Bernard Farkas, and Moebius to form the publishing house Les Humanoïdes Associés and the magazine Métal Hurlant.

[1] More recently, he created the artwork and designed large parts of the background of the 2005 TV miniseries remake Les Rois maudits (The Accursed Kings).