Lewis has also appeared in series such as Lizzie McGuire, Friends, The Wayans Bros., Yes, Dear, Scrubs, and How I Met Your Mother.

He has appeared in smaller roles in other films, including City Slickers (1991), Bowfinger (1999), I Spy (2002), Surviving Christmas (2004), Kicking & Screaming (2005), and Beverly Hills Chihuahua 2 (2011).

Lewis has also had recurring roles on A Different World, The Wayans Bros., Lizzie McGuire, Yes, Dear, Scrubs, and Raising Hope.

Lewis co-starred in the Disney Channel original series The Suite Life of Zack & Cody as Mr. Moseby.

His other television directing credits include Malibu Country, Mike & Molly, 2 Broke Girls, The Soul Man, Sullivan & Son, Melissa & Joey, Young & Hungry, The Odd Couple, One Day at a Time, and Indebted.

In late December 1991, Lewis was arrested after he fatally struck Isabel Duarte, a resident of Bethesda, Maryland, in a car crash.