Natalie's toad-headed agama (Phrynocephalus ananjevae) is a species of agamid lizard endemic to the Zagros Mountains in Iran.

[2][1][3] The specific epithet honours Natalia Ananjeva of the Zoological Institute in St. Petersburg, Russia for her contribution to herpetological research of the family Agamidae and Phrynocephalus in particular.

[2] P. ananjevae is one of the 34 recognized species within the genus Phrynocephalus.

It is a medium-sized Phrynocephalus with enlarged scales on the dorsal side of the body forming a prominent crest on the neck.

It has a tail shorter or equal to the body and a row of enlarged scales along the spine.