Some species of the genus Phyllomedusa produce a waxy secretion that reduces the evaporative water loss of their bodies.

If they begin to dry out, they move their limbs over their backs, where the secretory glands are, and spread the lipid secretion over their entire skin.

[2] Some indigenous groups from South America use the secretions of Phyllomedusa bicolor, the giant leaf frog, in shamanic hunting practices and as a traditional medicine ritual known as Kambo cleanse.

Species of the genus Phyllomedusa deposit their eggs on a leaf surface, interspersed with hydrating jelly capsules.

These nests are made above water, so the tadpoles drop into a suitable habitat, where they begin their lives as filter feeders.