The pair will move towards their oviposition site, usually on a leaf overhanging a body of water, where the male will assist the female in laying her eggs while simultaneously fertilizing them.

Upon hatching, tadpoles are equipped with relatively large external gills, an oral disc with multiple lines of keratinized teeth, and a tail that composes about two thirds of their body length.

[8] As in other species in the family of leaf frogs, it has physiological and behavioral adaptations to limit water loss, reducing it through the skin by lipid secretions and excretion of uric acid (uricotelism), as well as entering diurnal torpor.

[9] Lipid secretions are produced in a special type of cutaneous gland which is densely packed along the entire surface of the frog's body.

If handled, frogs will use their legs to engage in wiping behavior, possibly as a grooming mechanism or to ensure their bodies are appropriately coated in secretions.

The function of these secretions is undecided, varying in literature; a beneficial hydrophobic layer is supported by Blaylock et al., 1976,[9] versus a hygroscopically-induced water film barrier by Toledo and Jared, 1993.

[9] Waxy monkey leaf frogs generate many different pharmacologically active peptides as part of the defensive secretions covering their skin.