[citation needed] Beginning his career in St. Etienne where he won three Michelin Stars, Gagnaire tore at the conventions of classic French cooking by introducing jarring juxtapositions of flavours, tastes, textures, and ingredients.

On his website, Gagnaire gives his mission statement as the wish to run a restaurant which is 'facing tomorrow but respectful of yesterday' ("tourné vers demain mais soucieux d'hier").

[citation needed] The restaurant, Pierre Gagnaire, specializes in modern French cuisine and has garnered three Michelin stars.

[4][5][6] In December 2009, Gagnaire made his United States debut with Twist, a new restaurant at the Mandarin Oriental in Las Vegas, which received a Forbes Five-Star Award[citation needed] but has since closed.

Pierre Gagnaire has made appearances on Fuji TV's Iron Chef.