Nash was founder and CEO of Sympatic Inc[8] from 2029 to 2023, developing Cloud SaaS to power ethical data sharing for applications such as Artificial Intelligence.

From 2014 to 2017, Nash was Director of the Center for Data-Intensive Science at the University of Chicago that was building and managing the National Cancer Institute Genomic Data Commons with Robert Lee Grossman.

His work at the University of Chicago focused on understanding the SH2 domain at a systems level and investigating the role of ubiquitination in controlling endocytosis and modulating signal transduction.

His description of how complex protein interplay creates a digital switch guiding initiation of DNA replication published in Nature was a seminal advance covered as a breakthrough of the year by Science Signaling and remains extensively cited.

This emergent properties of a complex system as the basis for ultrasensitivity (all-or-none switches) at critical junctures in the cell cycle[12] remains a key example in this field.