Pignataro Maggiore is a comune (municipality) in the Province of Caserta in the Italian region Campania, located about 40 kilometres (25 mi) north of Naples and about 20 kilometres (12 mi) northwest of Caserta.

Pignataro Maggiore borders the following municipalities: Calvi Risorta, Francolise, Giano Vetusto, Grazzanise, Pastorano, Sparanise, Vitulazio.

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