Santa Maria la Fossa is a comune (municipality) in the Province of Caserta in the Italian region Campania, located about 30 kilometres (19 mi) northwest of Naples and about 15 kilometres (9 mi) west of Caserta.

Santa Maria la Fossa borders the following municipalities: Capua, Casal di Principe, Grazzanise, San Tammaro.

Footballer Attilio Lombardo was born in Santa Maria la Fossa.

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