The so-called Mackó cave, located near the northwest border of Pilisborosjenő, provided shelter to people all the way back in the Ice Age.

Other than artifacts from the Ancient Period, they have found relics from the Bronze Age and Roman times, as well as ones dating back to the Árpád era.

When Romans settled here there was a road leading to Aquincum at the base of Mount Nagy-Kevely, which is located at the northern border of Pilisborosjenő.

This is how they reached the area of modern-day Pilisborosjenő: archaeologists found an Avar cemetery where a brick factory is now located.

In the first half of the 17th century, it was one of several noble estates located in Pest County, owned by Bornemissza Pál Bolgár of Buda; the settlement was then taken over by Barnabás Muslay, a vitéz (Hungarian knight) from Komárom.