Piperacillin/tazobactam, sold under the brand name Tazocin among others, is a combination medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam.

[5] Common adverse effects include headache, trouble sleeping, rash, nausea, constipation, and diarrhea.

[5] Its main uses are in intensive care medicine (pneumonia, peritonitis), some diabetes-related foot infections, and empirical therapy in febrile neutropenia (e.g., after chemotherapy).

[citation needed] Piperacillin-tazobactam is recommended by the National Institute for Health and Care Excellence as first-line therapy for the treatment of bloodstream infections in neutropenic cancer patients.

[9] Piperacillin with tazobactam is administered through an intravenous (IV) method, where it is infused into the bloodstream over a period of 30 minutes to 4 hours so that the medication is delivered slowly and steadily.