Derani began his car racing career by driving in the Formula Renault 2.0 Northern European Cup with Motopark Academy in 2009.

He also drove in three Formula 3 Euro Series races and finished sixth in the Macau Grand Prix.

The Brazilian also drove at seven rounds of the 2017 WeatherTech SportsCar Championship for Extreme Speed Motorsports with a Nissan Onroak DPi, winning at Road America.

For the 2018 WeatherTech SportsCar Championship, Derani became a full-time driver at Extreme Speed Motorsports, winning at the 12 Hours of Sebring.

He was leading Petit Le Mans when he and Ricky Taylor made contact, knocking Derani's entry from contention.

[12] In December 2024, Derani and Andre Lotterer were announced the drivers for the new Genesis LMDh program which intends to compete in the World Endurance Championship for the 2026 season.