In early Drosophila development, the embryo passes through thirteen nuclear divisions (karyokinesis) without cytokinesis, resulting in a multinucleate cell (generally referred to as a syncytium, but strictly a coenocyte[1]).
Late in oogenesis, polar organelles, which are electro-negative granules, are in the pole plasm.
When the pole plasm further matures, it continues to consist of polar granules into the development of germ cells, which develop into adult germ cells.
[6] Pole cells begin their migration in a cluster in the midgut primordium.
To reach their final destination, pole cells must migrate through the epithelial wall.