[6][7][8] The gene PKD2 also known as TRPP2, encodes a member of the polycystin protein family, called TRPP, and contains multiple transmembrane domains, and cytoplasmic N- and C-termini.

TRPP2 may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homeostasis and other signal transduction pathways.

This protein interacts with polycystin 1 (TRPP1) to produce cation-permeable currents.

Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.

This article on a gene on human chromosome 4 is a stub.