The Polytechnic University of the Philippines Laboratory High School (Filipino: Sanayang Mataas na Paaralan ng Politeknikong Unibersidad ng Pilipinas), abbreviated as PUPLHS, is the laboratory school of the Polytechnic University of the Philippines College of Education located in PUP Mabini Campus, Sta.

However, in June 1963, the curriculum was revised to improve areas of social, physical, and biological sciences.

[citation needed] Since the 1970s the school has been operating in its current compound located within the Mabini Campus of PUP.

[4] Admission to PUPLHS requires passing the PUP Laboratory High School Entrance Exam (LHSEE).

[6] PUPLHS has 16 organizations, clubs, and teams that covers the students' wide range of interests.

Since its organization in 2003, it has won several awards from different local, national and international choir competitions, including the grand prize in the Philippine Travel Mart Eco Chorale Competition High School Division last September 5, 2010; Gold diploma and 2nd prize in the 1st Vietnam International Choir Festival and Competition held in Hoi An, Quang Nam, Vietnam last March 14, 2011 for the Mixed Youth Choir category; and two silver certifricates in the 4th Voyage of Songs International Chorale Festival held in Penang, Malaysia last July 4–8, 2009; Gold Diploma in the 1st Guam Pacific Choral Festival at Hagatna, Guam last May 1–5, 2012, among others.

It regularly performs during school programs and also for diplomats and tourists in various functions in the Malacañan Palace, the Department of Tourism, the Philippine Convention and Visitors Corporation known now as Tourism Promotions Board, the Cultural Center of the Philippines and other public and private institutions.

It is composed of drummers (snare, bass, and quad), lyrists, cymbalists, majorettes and color guards.

They host Oratorical and Debate competitions and training that they use to spread awareness and confidence in public speaking.

Among the well-known people who have attended the school are Filipino government officials Securities and Exchange Commission Commissioner Antonieta Fortuna-Ibe, and Former Undersecretary Celia Capadoccia Yango.

Businessmen Noel Gonzales, Reynaldo Garcia, Joey Bermudez also attended the school.

Multi-awarded Social Advocate Jo Enrica Enriquez-Rosales, Magno-Humphries Drug Manufacturing Company founder Thelma Magno-Humphries, TV and movie director Lamberto De Leon and Banco de Oro Vice President for Informational Technology Rolino Bucao, Jr. are graduates of the school.

[13] Notable people who have taught in the school include Palanca Awardee for Literature and Poetry Luwalhati Alvero-Kendrick.