Polytechnic University of the Philippines, Santa Maria, Bulacan Campus or PUP-SMBC (Filipino: Politeknikong Unibersidad ng Pilipinas, Sudlong ng Santa Maria) is a PUP extension campus in Sitio Gulod, Brgy.

Pulong-Buhangin, municipality of Santa Maria, Bulacan province, Philippines, offering undergraduate programs.

Professor Emilia C. Mateo, MAT, MBE served as the extension's first directress, followed by Prof. Arlene R. Queri then Prof. Orlando Batongbakal (as OIC), Engr.

Aureluz L. Torres, Prof. Kathryn Placido (as Acting Director), Lualhati dela Cruz, Prof. Jose M. Abat and Prof. Ricardo F. Ramiscal took the position followed by Prof. Artemus G. Cruz, Dr. Marissa Baybay and the current director is Prof. Len Isip.

Last September 2018, PUP Santa Maria Bulacan Campus celebrated its 13th Founding Anniversary.