Born into an ancient House of Pernšejn, she was the daughter of the Imperial High Chancellor of Bohemia, Vratislav II of Pernštejn (1530–1582), and his wife, Maria Maximiliana Manrique de Lara y Mendoza (1538-1608), a Spanish noblewoman.
Maria Pernštejn presented the statue to her daughter, upon Polyxena's marriage to the High Burgrave Wilhelm von Rosenberg in 1587.
[2] This marriage produced only one son, Wenzel Eusebius von Lobkowicz, whom she gave birth to in 1609 at the age of 42.
In 1618, the aging Emperor Matthias named his cousin Ferdinand of Styria his heir, and had him crowned King of Bohemia.
She is the ancestor of several royal families, including that of the Russian Emperors, the Kings of Denmark, Greece, Norway and Great Britain, and others.