Pond Creek is a tributary of the Ohio River, 16 miles (26 km) long,[3] in western West Virginia in the United States.

It rises south of Rockport and flows generally west-northwestward through the unincorporated communities of Lowdell, Jerrys Run, and Flinn.

It flows into the Ohio River on the boundary of Jackson and Wood counties, at the community of Pond Creek.

Little Pond Creek flows in Jackson County for most of its course, northwestward through the communities of Willowdale and Topins Grove.

[5] According to the West Virginia Department of Environmental Protection, approximately 82% of the Pond Creek watershed is forested, mostly deciduous.