Port Byron is a village in Cayuga County, New York, United States.

It has been suggested that the new name may have been chosen in reference to Lord Byron, the English romantic poet who had died the previous year, however there is no definitive proof of this.

The Erie Canal Lock 52 Complex was listed on the National Register of Historic Places in 1998.

There are a number of people who can trace their roots back to Port Byron or who settled here for a while.

We can trace Isaac Singer of sewing machine fame here in 1837, when he was better known for his acting than his machinery skills.

She also wrote a book about her childhood, titled A Life Unveiled, written under the name "A Child of the Drumlins".

Physicist Dr. Francis Eugene Nipher, a professor at Washington University in St. Louis, is well known for his early work on the effect of electrical charges on attractive and repulsive forces.

Edward G. Delaney, an aerospace scientist and mechanical engineer who worked on the iconic Mercury, Gemini, and Apollo space programs is a Port Byron High School Hall of Fame member and 1948 graduate.

The New York State Thruway passes through the northwest corner of the village but with no direct access.