Scipio is a town in Cayuga County, New York, United States.

[3] Scipio is centrally located in the southern half of the county, south of Auburn.

Scipio was part of the Central New York Military Tract, which was land reserved as payment by the federal government to veterans of the Revolutionary War.

[4] In 1823, part of Scipio was used to form the towns of Ledyard, Springport, and Venice.

20.0% of all households were made up of individuals, and 8.8% had someone living alone who was 65 years of age or older.

The 19th-century store is significant for its cobblestone architecture and was listed on the National Register of Historic Places in 1994.