Port Gibson High School is a public high school in unincorporated Claiborne County, Mississippi, with a Port Gibson.

The old Port Gibson High School campus is now used by Port Gibson Middle School and is listed on the National Register of Historic Places.

[4][5] Port Gibson High School was for whites only prior to integration.

[6] Port Gibson High School had a librarian and a music program.

[8] In 1995, Glendora Alexander-Muhammad who taught business education and computer science at Port Gibson High School planned to accompany 30 school girls to the Women in Science and Technology ( WIST ) program event.