Port Royal is a ghost town in Coahoma County, Mississippi, United States.

Port Royal is the oldest town in Coahoma County, with land sales recorded prior to 1836.

[2] Port Royal was the largest and busiest town in Coahoma County, with a landing for steamboats and a few small trading stores and cabins.

[1][3] John Clark, the founder of Clarksdale, landed at Port Royal when he first arrived in the county.

As told in 1905, "In this process, many beautiful plantations that bordered on the old river bed were abandoned and are now covered with cottonwood trees.