Over 80 tenant customers lease facilities on the 1,900-acre campus and employ nearly 16,000 people, generating approximately $5.6 billion in annual economic activity for the region.

In the last decade, several cybersecurity, robotics, space-based manufacturing, automotive and other advanced technology entities have launched operations at the site.

As the home for the San Antonio Museum of Science and Technology (SAMSAT), the Port is also a hub for several STEM/STEAM-based educational programs serving schools throughout the region.

As realignment and closure of the Kelly assets began to occur between 1995 and 2001, the Greater Kelly Development Authority (GKDA) was created as a base development authority in accordance with Chapter 379B of the Texas Local Government Code.Rebranded as Port San Antonio in 2007, it is a political subdivision of the state of Texas.

Port San Antonio is home to large operations by The Boeing Company, StandardAero, Chromalloy and Knight Aerospace.

In recent years, a number of applied technology firms—such as India-based Indo-MIM, Plus One Robotics, Netherlands-based XYREC and space-based manufacturing venture Astroport Space Technologies—have established a presence at the Port.

[5] The campus is home to the San Antonio Museum of Science and Technology (SAMSAT), a non-profit organization that delivers educational programs, camps, demonstrations and other activities to area students.

Informally known as Lackland Annex, the office facilities totaling 690,000 square feet serve as national headquarters for several Air Force and other Department of Defense operations.

[10] In June, 2022, the upcoming development of three new projects on the main campus was announced: a multi-story office tower to accommodate expansions by the DeLorean Company, a vertiport, and a research complex that will include a simulated lunar habitat facility.