Portrait of a Man is an oil painting by the Italian Renaissance artist Antonello da Messina, dated to c. 1475–76, and now in the National Gallery, London.

He wears a leather blouse, under which a white shirt is visible, and a red cloth cap.

Antonello uses layers of colour with graduations of tones to build up a portrait with a realistic three-dimensional appearance.

The composition, a strongly illuminated and tightly cropped three-quarters view set against a dark background, departs from the Italian tradition of the time, and is derived from the Flemish school, including Petrus Christus, whom Antonello knew personally in Italy.

The work is one of twelve surviving portraits by Antonello, all bust-length head-and-shoulders views of men and mostly against dark backgrounds.