Powell's Creek is a tributary of the James River on the south side of the James River in Prince George County, Virginia, United States.

The creek borders James River National Wildlife Refuge near Garysville, Virginia.

According to the Tobacco Inspection Act, the inspection was "In Prince George; at Appamatox Point, upon Col. Bolling's land; on Col. Robert Mumford's land; and Powel's Creek; upon Mr.

According to a State of Virginia historical marker, "The creek ... was named for Nathaniel Powell, acting governor in 1619.

Here Grant's army, after crossing the James, turned towards Petersburg, June, 1864.