Pozzuolo Martesana (Lombard: Pozzoeu or Pozzoeul [puˈsøː(l)]) is a comune (municipality) in the Metropolitan City of Milan in the Italian region Lombardy, located about 25 kilometres (16 mi) east of Milan.

Pozzuolo Martesana borders the following municipalities: Inzago, Cassano d'Adda, Gorgonzola, Bellinzago Lombardo, Melzo, Truccazzano.

Pozzuolo Martesana is served by Pozzuolo Martesana railway station, the village of Trecella by Trecella railway station.

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