San Donato Milanese (Milanese: San Donaa [ˌsãː duˈnaː]) is a comune (municipality) in the Metropolitan City of Milan in the Italian region of Lombardy, located about 10 kilometres (6 mi) southeast of Milan.

Although the area was settled in ancient times, the origins of San Donato date back to the 7th century, when a pieve was founded here by the army of Grimoald I, Duke of Benevento.

After a period under the Milanese family De Advocati, the town was a possession of the archbishops of Milan until the 16th century.

On 3 October 2021, a private plane crashed into an empty building under renovation on San Donato Milanese after taking off from Milan to go to Olbia.

One of the deceased was Dan Petrescu, a Romanian businessman and billionaire, one of the richest people in Romania at the time and the owner of the plane.