San Zenone al Lambro (Milanese: San Zenon [ˌsãː dzeˈnũː], locally San Zanon [ˌsãː dzaˈnũː]) is a comune (municipality) in the Metropolitan City of Milan in the Italian region Lombardy, located about 20 kilometres (12 mi) southeast of Milan.

San Zenone al Lambro borders the following municipalities: Vizzolo Predabissi, Tavazzano con Villavesco, Cerro al Lambro, Sordio, Lodi Vecchio, Casaletto Lodigiano and Salerano sul Lambro.

It is served by San Zenone al Lambro railway station.

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