John F. Funk bought a plot of land for the church building just outside the city limit to allay concerns about how the Mennonite faith would hold up in an urban context.
[4] In 1931, the Prairie Street Mennonite Church building was burned in a fire so severely that it needed to be rebuilt.
Nellie Mann Witmer, Minnie Graber, and Juanita Mann Wittrig, all Prairie Street members, served as president of the Indiana-Michigan Women's Missionary and Service Commission and Graber also served as the president of the church-wide WMSC from 1958-1969.
Located in a neighborhood equal parts African-American, Caucasian, and Hispanic, Prairie Street initiated programs designed to reach out to the community, including Vacation Bible School (with Hively Avenue Mennonite), neighborhood block parties, and Jubilee House, a unit of Mennonite Voluntary Service.
[7] In 2008, MVSers at Jubilee House appeared dressed as superheroes to promote awareness of male-pattern violence.