It was seriously considered that the seat of the Basel Mission and Presbyterianism needed a higher school.

Currently, the school has benefited from the GETFund,[2] and new classroom blocks are being put up to accommodate the many students who continue to seek academic progress here.

Currently, the school has benefited from the GetFund and new classroom blocks are being put up to accommodate the many students who continue to seek academic progress here.

It was to offer Presbyterian day secondary education to children whose parents could not afford the boarding fees of the sister school at Presbyterian Boys Senior Secondary school then located at Odumase - Krobo which was later moved to Legon.

Vincent The Presbyterian High School-Osu triumphed over Mfantsipim to win the Sprite Ball Championship for the first time Presbyterian Senior High School (Osu PRESEC) have annexed the 2017/2018 Sprite Ball Championship after beating Mfantsipim School 25-22 in a pulsating final.

The journey for Mfanstipim in the knockout phase started after beating Prempeh College 20-16 quarter final.

Beating the four time winners of the prestigious competition, caps off a remarkable run by the little known school after going unbeaten in the tournament.