While the current territory of the presbytery consists of four counties in the southwestern Pennsylvania, originally it stretched from the Allegheny Mountains to the east, as far north as Lake Erie, to the south to Virginia and “on the west by the setting sun.”.

Redstone would have originally included all of the following present-day Presbyteries, Redstone Kiskiminetas, Pittsburgh, Washington, Beaver-Butler, Shenango, Lake Erie, Upper Ohio Valley, and West Virginia.

David McClure met with a group of settlers to worship God at the current church site, then known as Jacob’s Swamp.

Dr. James Power, then 31 years old, brought his wife and four young daughters across the Alleghenies on horseback (with only three horses) to become the minister of Middle Presbyterian Church and the first ordained minister of any denomination to settle with a family in Western Pennsylvania.

The first meeting of the presbytery on Sept. 19, 1781 was held at Pigeon Creek Church instead of Laurel Hill as originally planned because the incursions of Native Americans rendered it undesirable for the ministers and elders to go to Laurel Hill.