[8] Subsequent in vitro and in vivo studies have shown it to have both primase and polymerase activities that both localise to the catalytic domain of PrimPol.

PrimPol exhibits a 1000-fold bias towards Watson-Crick base pairing when extending DNA chains.

[6] PrimPol is able to bypass the highly distortive Pyrimidine dimers produced as a result of UV irradiation of DNA in vitro.

[7] The replicative DNA polymerase identified in the mitochondria, pol γ, deals with these lesions poorly.

[7] The mitochondrial fraction of PrimPol is found to be in the matrix of the mitochondria, as opposed to the either the membrane or intermembrane space.