The Primera División de Fútbol Profesional Apertura 1999 season (officially "Copa Pilsener Apertura 1999") started on August 28, 1999, and finished on December 26, 1999.

The season saw Águila win its 12th league title after a 1-0 victory over Municipal Limeno in the final.

Promoted from Segunda División de Fútbol Salvadoreño as of 1999.

Relegated to Segunda División de Fútbol Salvadoreño as of 1999.

Luis Ángel Firpo Juventud Olimpico Municipal Limeno Santa Clara