The Primera División de Fútbol Profesional Apertura 2000 season (officially "Torneo Apertura 2000") started on August 26, 2000, and finished on December 30, 2000.

Águila win its 12th league title after a 3–2 victory over C.D.

This is a list of foreign players in Apertura 2000.

Atletico Balboa Atletico Marte (player released mid season) (player Injured mid season) Injury replacement player Dragon

Luis Ángel Firpo Municipal Limeno Santa Clara