The Primera División de Fútbol Profesional Apertura 2006 season (officially "Torneo Apertura 2006") started on August 12, 2006 and concluded on December 17.

The fourth place match was played on November 30.

The team with the lower league position played home in the 1st leg.

Luis Ángel Firpo (player released mid season) Injury replacement player

Independiente Nacional 1906 A.D. Isidro Metapán Once Municipal San Salvador F.C.