This thus made her a niece of George II of Great Britain, who was the king from 1727 to 1760 and died at age 77 when she was 46,and a cousin of Frederick, Prince of Wales, Anne, Princess of Orange, and Queen Louise of Denmark and Norway.

On 30 May 1729 in Berlin, Friederike Luise married her Hohenzollern kinsman Karl Wilhelm Friedrich, Margrave of Brandenburg-Ansbach (12 May 1712 – 3 August 1757).

Even on the trip to Ansbach in June 1729 for her wedding, Luise Friederike was suffering from symptoms of the metabolic disease porphyria.

Crown Prince Frederick of Prussia commented on the marriage in February 1732 in these terms: "My sister and her husband, the Ansbacher hate each other like fire."

At a window in the family room of the Ansbacher Residenz, she scratched this plea with a diamond in the glass:" Je souffre sans oser le dire. "