Princess Marie Luise Charlotte of Hesse-Kassel (9 May 1814 – 28 July 1895) was a member of the House of Hesse-Kassel by birth.

Through her marriage to Prince Frederick Augustus of Anhalt-Dessau, she became a princess of Anhalt-Dessau.

Marie Luise Charlotte was the second child and daughter of Prince William of Hesse-Kassel and his wife Princess Louise Charlotte of Denmark.

[citation needed] She was an elder sister of Louise of Hesse-Kassel, consort of Christian IX of Denmark: Her other siblings included Prince Frederick William of Hesse-Kassel and Princess Auguste Sophie Friederike of Hesse-Kassel.

Marie Luise Charlotte married Prince Frederick Augustus of Anhalt-Dessau, fourth but third surviving son of Frederick, Hereditary Prince of Anhalt-Dessau and his wife, Landgravine Amalie of Hesse-Homburg, on 11 September 1832 at Rumpenheimer Schloss in Offenbach am Main.