Princess Louise Caroline of Hesse-Kassel (German: Luise Karoline von Hessen-Kassel; 28 September 1789 – 13 March 1867) was the consort of Friedrich Wilhelm, Duke of Schleswig-Holstein-Sonderburg-Glücksburg and the matriarch of the House of Glücksburg.

Louise Caroline was born at Gottorp, Schleswig, in the Duchy of Schleswig, to Prince Charles of Hesse-Kassel (19 December 1744 – 17 August 1836) and his wife Princess Louise of Denmark (30 January 1750 – 12 January 1831).

Her elder sister Marie Sophie of Hesse-Kassel (28 October 1767 – 21 March 1852) became Queen consort of Frederick VI of Denmark.

He succeeded his childless maternal second cousin, Frederick VII of Denmark, on 15 November 1863, the Hereditary Prince Ferdinand having deceased somewhat earlier.

Her grandchildren included (among others) King Frederik VIII of Denmark, Queen Alexandra of the United Kingdom, Empress Marie Feodorovna of All the Russias, King George I of the Hellenes and Crown Princess Thyra of Hanover.