The hospital was established in 1914 as South Carolina Baptist Hospital by the South Carolina Baptist Convention after the widow of Dr. Augustus B. Knowlton, a prominent Columbia physician, asked the church to purchase the hospital, at that time a 70-bed facility on Marion St., that she and her husband started.

Over the years, the hospital expanded and grew as additional services were offered.

In 1998, the two-hospital Baptist Healthcare System merged with Richland Memorial Hospital to form Palmetto Health, the largest healthcare system in South Carolina at the time.

In 2017, Palmetto Health merged with the Greenville Hospital System to form Prisma Health and continues as the largest not-for profit hospital operator in South Carolina.

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