Prospero Colonna (November 27, 1662 – March 4, 1743) was a Roman Catholic cardinal.

He is also known as Prospero II Colonna to differentiate him from his elder relative cardinal Prospero I Colonna (1410–1463).

Prospero Colonna was born on 27 Nov 1662 in the Castle di Marino, Marino, Lazio near Rome,[1][2] the second child of Filippo Colonna and Cleria Cesarini.

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