Route 57 is a major road located in Winnipeg, Manitoba.

It connects the suburbs of St. James and St. Boniface with the West End and the downtown core.

East of Portage Avenue, Route 57 passes by Shaw Park and The Forks as it follows Pioneer Avenue (westbound) or William Stephenson Way (eastbound) via Main Street.

Notre Dame Avenue (not to be confused with Notre Dame Street in St. Boniface) was named for a girls' school which was located on the road (it later moved to Academy Road).

William Stephenson Way (formerly Water Avenue) is named after the British-Canadian spy, who was born in Winnipeg.