[4] All cultivated species of the genus Prunus, which includes plums, cherries, apricots, almonds, and peaches, are susceptible to one or more strains of PNRSV.

[5][6] Other susceptible hosts used for diagnosis include Chenopodium quinoa Willd.,[7] sunflower (Helianthus annus), and Momordica balsamina.

[9] In sweet cherries, PNRSV causes reduced leaf size and produces diffused chlorotic rings and/or spots.

PNRSV can be transmitted through plant propagation methods, making spread through tree nursery stock and root grafting in orchards problematic.

As of September 2021, there have been 631 PNRSV isolates from 33 countries deposited in NCBI GenBank, showing that the virus is a great international traveler.

Phylogenetic and population genetic analyses indicated that the common ancestor of current PNRSV isolates was originated from America continent.