They have been found in a variety of habitats including the Great Barrier reef (Queensland, Australia), the Red Sea, and Jamaica.

Notably, a species in this genus produces a chemical that is effective in inhibiting the migration of metastatic breast cancer cells.

[2] Several species have been described as yellow in color, but oxidizes in air and turns a dark yellowish-green, with variations in growth type including plates, tubes, and spikey branching arms.

[3] The species Pseudoceratina crassa is a brooder which releases its larvae once a year during daylight hours which are yellow and between 1.5–2.0 millimeters.

It is unsure why, but the larvae are considered distasteful by fish species thus survival rate is not significantly affected by predation.

[7] Pseudoceratina crassa is one of the most prevalent species of sponges found on the north coast of Jamaica in Discovery Bay Reef where their growth rate was measured following Hurricane Allen in 1980.