Puerto Rico Highway 100 (PR-100) is a secondary highway in southwestern Puerto Rico, located mostly in the municipality of Cabo Rojo.

[3] Beginning at its intersection with PR-2 in Hormigueros, Puerto Rico, the highway runs south for about 15 kilometers and is main gateway to local tourist destinations such as Boquerón, Combate (via PR-301 and PR-3301) and Puerto Real.

It is mostly divided, but in the end it is three lanes (2 to go and 1 returning, and later backwards).

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