Puerto Rico Highway 501 (PR-501) is a tertiary[3] state highway in Ponce, Puerto Rico.

The road runs north to south, and mostly alongside Rio Pastillo in barrio Marueño.

It southern terminus is at PR-123, just off Calle 18 of Urbanización Las Delicias in barrio Magueyes, and its northern end is also at PR-123 but in barrio Guaraguao.

The entire route is located in Ponce.

This Puerto Rico road-related article is a stub.