The highway has both of its endpoints, as well as all of its length, entirely within the Ponce city limits.

In the 2000s decade, PR-500 was no longer transited by the oversized Ponce Cement (now CEMEX) trucks.

It is lined by residential areas with a short section lined by the Calle Villa Final industrial park, a light-industry industrial park.

[3][4] The highway is a wide two-way roadway originally designed to accommodate the oversized trucks used by the Ponce Cement, Inc. plant in barrio Magueyes, on road PR-123.

[5][6] The road runs from its eastern terminus at PR-132 (Calle Villa), which is the road leading from Guayanilla to Ponce through Peñuelas, to its western terminus at Barrio Canas where it ends at the Ponce Municipal Waste and Recycling Yard.