The road runs north to south, joining PR-14, where PR-506 starts, to PR-52 interchange, where it ends.

The road is located entirely within Barrio Coto Laurel and its length is 2.0 km (1.2 mi).

[3] In its short 2.0 km (1.2 mi) length, PR-506 is home to Hospital San Cristóbal, Bolera Caribe, National University College, a pharmacy, a branch of the United States Post Office, a bank, and many restaurants, among other businesses and few neighborhoods located in Barrio Coto Laurel.

The southern end of PR-506 also provides access to Industrias Vassallo[4] and Cristalia Premium Water[5][6] industries.

This is a two-lane tertiary road which intersects with PR-1 and the southern terminus of PR-10, an important primary highway.