Puerto Rico Highway 64 (PR-64) is a short divided highway in Mayagüez, Puerto Rico which serves as an alternate route to Puerto Rico Highway 2, beginning at Puerto Rico Highway 102 toward barrio Sabanetas.

It is also a route to the Mayagüez Port, where a ferry can be taken to Santo Domingo, Dominican Republic.

[4] The entire route is located in Mayagüez.

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