Puerto Rico Highway 65 (PR-65) is a short highway connecting Puerto Rico Highway PR-239, also locally known as Alfonso Valdés Cobián Boulevard (formerly known as Calle Post and PR-2R) near University of Puerto Rico at Mayagüez, to Puerto Rico Highway 106.

[2] It has not an intersection to the main highway PR-2, but can be accessed quickly going west of the alt route.

It is also the main highway to the Palacio de Recreación y Deportes (Sports and Recreation Palace) and to the Parque de los Próceres.

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