Puerto Rico competed at the 2012 Summer Olympics in London, United Kingdom from July 27 to August 12, 2012.

Comité Olímpico de Puerto Rico sent a total of 25 athletes to the Games, 19 men and 6 women, to compete in 8 sports.

Four Puerto Rican athletes had competed in Beijing, including track star and pre-Olympic favorite Javier Culson, who held the record as the "world's fastest man" in the hurdles, and later became the nation's flag bearer at the opening ceremony.

Canterbury Christ Church University had been selected as the team's preparation base for these Olympic games.

Meanwhile, Dominican born Jaime Espinal became the first Puerto Rican athlete to claim an Olympic silver medal in men's freestyle wrestling, and set a historic Olympic record as the nation's second silver medalist, 28 years after Luis Ortiz had become the first.